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You actually need several large syringes full of air in your heart to stop it (acording to my doctor friend).
The danger is as you pointed out - if blood flow is stopped "downstream". Clots usually do this better though...
My friend, martial arts instructor, aerobics instructor, fit as fcuk, ended up in hospital with multiple clots on his lung - for no reason. He's damaged a large part of his lung as a result, and I don't think it grows back. Poor sod.
I don't know if the same damage can happen from sawtooth or reverse profile, but if it could, I expect we'd all be a bit more careful...
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