Bodybuilding, Nitrix Oxide and diving...

[calski]

Hi Everyone

I've done a quick search through the forums for NO (Nitric Oxide) and can't see anything which answers my question.

Basically, I am a keen weight trainer / amateur bodybuilder and as such take a whole range of supplements. One of them is an NO based product which increases muscular vascularity and thus "pumps" whilst working out. I take this 30 minutes prior to a gym session (5 - 6 times per week).

My question is whether I am increasing / decreasing the likelihood of a bend. Originally, I thought I was probably increasing the chances of a bend but having read some of the posts from other threads, I'm not so sure.

Since many (most) NO products are now banned in Ireland (No-Xplode, Superpump250 etc etc...) I have to order via the UK and collect them when I go home. I wasn't planning on taking any NO supplementation with me when I travel to Egypt with ancl but since reading the posts outlining potential benefits, I'm giving it some thought.

Are there any doctors / medical professionals / bodybuilders on YD who know about this or have an opinion? A friend of mine in the US feels there are no risks but he's a bodybuilder, not a medical professional / scientist.

Thanks in advance!

calski

[Mark Powell]

There have been some studies into this;

Exercise and nitric oxide prevent bubble formation: a novel approach to the prevention of decompression sickness? -- Wisløff et al. 555 (3): 825 -- The Journal of Physiology Online

NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats -- Wisløff et al. 546 (2): 577 -- The Journal of Physiology Online

[DevonDiver]

Yes, that's what I thought.

What do you think Mark...is it safe or not?

[Sipadan]

Hi Calski. I have some experience in nitric oxide biology research. First off, I'm sceptical about these products. "NO-based" means nothing to be be honest. If they had an appreciable immediate affect on blood flow, then your blood pressure would be through the floor and you'd be passing out all the time or worse.

If it's purpose is to increase the number of blood vessels in the muscle, then again, I'm sceptical, but it is more plausable. However, you never know, so:

NO dilates blood vessels. I don't know much about DCS biology, but this is generally thought to be a good thing, so it might actually reduce your chance of a hit.

The fact that it's another source of nitrogen is probably not relevent due to the form that's in.

It's all speculation on my part, I don't know and I doubt that anyone does. People will have ideas, but as with so many areas of diving research, good, hard evidence in limited.

[calski]

Hi Sipadan

To give you an example of the kind of thing I take regularly, Superpump250 contains:

SuperPump250™ Proprietary Blend 20,000mg **
[Gaspari Nutrition Novel Compound #250 (Patent Pending)]
Anabolic Signaling Complex™ (Patent Pending)
Glucose Polymer Blend, Creatine Monohydrat, NO2 Complex [L-Arginine Alpha-Ketoglutarate (A-AKG), L-Arginine Ketoisocaproate (A-KIC)], Guanipro™ (Guanidino Propionic Acid), Salicyclic Acid 15%, American Ginseng Extract
Lipolytic/Xtreme Focus Agent™ (Patent Pending)
L-Tyrosine, Methylxanthines (Caffeine), NAC (N-Acetyl-Cysteine), N-Acetyl-Tyrosine, Glucuronolactone, Rhodiola Rosea Root Extract (Standardized To 5% Total Rosavins), Ginko Biloba Extract (Standardized To 24% Ginkosides & 6% Terpenes), Vinpocetine, Huperzine
Myogenic Transcription Factor/Agonist™ (Patent Pending)
Taurine, L-Leucine, L-Glutamine, L-Valine, L-Isoleucine, L-Citruline AKG, Turkesterone (11,20 Dihydroxyecdysone From Ajuga Turkestanica Extract), Choline Bitartrate
Insulin Secretagogue Complex™
Trimethylglycine, Indole-3-Carbinol, 4-Hydroxyisoleucine (From Fenugreek Seed Extract), Cinnamon Bark Extract (15% Cinnamic Aldehyde), Bacopa Monniera (Standardized For 20% Bacosides A & B)
IntraSORB™ Rapid Absorption - Myo-Hydration Matrix
Sodium Bicarbonate, Potassium Bicarbonate, Potassium Gycerophosphate, Magnesium Glycerophosphate, Alpha Lipoic Acid, Bioperine™
† Percent Daily Values are based on a 2,000 calorie diet
** Daily Values not established

*******

I guess the L-Arginine Alpha-Ketoglutarate (A-AKG), L-Arginine Ketoisocaproate (A-KIC)], Guanipro™ (Guanidino Propionic Acid), Salicyclic Acid 15%, American Ginseng Extract blend is what stimulates the NO production?

I'm not looking for a definitive answer but a feel really for whether it's worth taking up some of my precious weight allowance with this supp...

As an aside, does anyone know if this stuff is legal in Egypt? I don't fancy standing in Sharm airport explaining what the white powder is

"Honestly guv, it's something that makes my veins pop out more!!!" (oo-er missus)...

[liamm]

[quote=Sipadan;909125]
NO dilates blood vessels. I don't know much about DCS biology, but this is generally thought to be a good thing, so it might actually reduce your chance of a hit.
quote]

I dive with asthma (controlled) and have been warned not to take my reliever inhaler (ventolin/salbutamol etc) before or directly after i dive as it dilates blood vessels in the lungs and so could lead to bubbles being passes from the venous side to the arterial side - similar to the effect of a PFO. Could NO lead to similar?

[Sipadan]

Wow, that's quite a recipe list you got there

I suspend some of my scepticism. There are certainly compounds in that that can act as NO-donors. Whether they do or not in the environment of your gastrointestinal tract or your blood once absorbed. I just don't know, sorry.

Personally, not professionally, if it was me and I wanted to take it, I would.

Don't know about the legality either.

Originally Posted by calski

Hi Sipadan

To give you an example of the kind of thing I take regularly, Superpump250 contains:

SuperPump250™ Proprietary Blend 20,000mg **
[Gaspari Nutrition Novel Compound #250 (Patent Pending)]
Anabolic Signaling Complex™ (Patent Pending)
Glucose Polymer Blend, Creatine Monohydrat, NO2 Complex [L-Arginine Alpha-Ketoglutarate (A-AKG), L-Arginine Ketoisocaproate (A-KIC)], Guanipro™ (Guanidino Propionic Acid), Salicyclic Acid 15%, American Ginseng Extract
Lipolytic/Xtreme Focus Agent™ (Patent Pending)
L-Tyrosine, Methylxanthines (Caffeine), NAC (N-Acetyl-Cysteine), N-Acetyl-Tyrosine, Glucuronolactone, Rhodiola Rosea Root Extract (Standardized To 5% Total Rosavins), Ginko Biloba Extract (Standardized To 24% Ginkosides & 6% Terpenes), Vinpocetine, Huperzine
Myogenic Transcription Factor/Agonist™ (Patent Pending)
Taurine, L-Leucine, L-Glutamine, L-Valine, L-Isoleucine, L-Citruline AKG, Turkesterone (11,20 Dihydroxyecdysone From Ajuga Turkestanica Extract), Choline Bitartrate
Insulin Secretagogue Complex™
Trimethylglycine, Indole-3-Carbinol, 4-Hydroxyisoleucine (From Fenugreek Seed Extract), Cinnamon Bark Extract (15% Cinnamic Aldehyde), Bacopa Monniera (Standardized For 20% Bacosides A & B)
IntraSORB™ Rapid Absorption - Myo-Hydration Matrix
Sodium Bicarbonate, Potassium Bicarbonate, Potassium Gycerophosphate, Magnesium Glycerophosphate, Alpha Lipoic Acid, Bioperine™
† Percent Daily Values are based on a 2,000 calorie diet
** Daily Values not established

*******

I guess the L-Arginine Alpha-Ketoglutarate (A-AKG), L-Arginine Ketoisocaproate (A-KIC)], Guanipro™ (Guanidino Propionic Acid), Salicyclic Acid 15%, American Ginseng Extract blend is what stimulates the NO production?

I'm not looking for a definitive answer but a feel really for whether it's worth taking up some of my precious weight allowance with this supp...

As an aside, does anyone know if this stuff is legal in Egypt? I don't fancy standing in Sharm airport explaining what the white powder is

"Honestly guv, it's something that makes my veins pop out more!!!" (oo-er missus)...

[Sipadan]

Originally Posted by liamm

I dive with asthma (controlled) and have been warned not to take my reliever inhaler (ventolin/salbutamol etc) before or directly after i dive as it dilates blood vessels in the lungs and so could lead to bubbles being passes from the venous side to the arterial side - similar to the effect of a PFO. Could NO lead to similar?

I don't know about that and I'm not going to bullshit. The idea behind vasodilators preventing DCS is that they allow for more efficient off gassing, whereas vasoconstrictors do the reverse.

[Ahmed Adly]

Originally Posted by calski

As an aside, does anyone know if this stuff is legal in Egypt? I don't fancy standing in Sharm airport explaining what the white powder is

"Honestly guv, it's something that makes my veins pop out more!!!" (oo-er missus)...

Personally, I love a good workout early morning, especially before a long days diving.

The great thing about Egypt and Pharmacuticals is how bloody leagal everything is. You can get EVERYTHING from the pharmacy that dose not make you high.
Viagra and Cialis seem to be the main sellers here. I know parents a guy who sends his some for Viagra because he is too shy to buy it for himself
So don't worry about bringing stuff in at all.

I would not dare comment on the DCS portion of your question. (although I really think it's OK to dive and take NO)

[Matt-75]

Originally Posted by liamm

I dive with asthma (controlled) and have been warned not to take my reliever inhaler (ventolin/salbutamol etc) before or directly after i dive as it dilates blood vessels in the lungs and so could lead to bubbles being passes from the venous side to the arterial side - similar to the effect of a PFO. Could NO lead to similar?

Have the same, and take salbutamol prior to diving as recommended by my diving doctor. Never had a bend, well never had a treatable bend, but have suspicion of having had a mild one a couple of years back due to diving in a 3mm in stoney, in late october, put it down to getting royally cold, but the DDRC told me to get a neuro which was fine, so no further action taken. SInce then done a fair few dives and never noticed a problem.

I actually prefer to take a steroid inhaler as it prevents the likelihood in advance. My doctor says with the two combined i shouldnt be seeing any problems.